A Two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways

A Two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways

Activation of oxidative stress-responses and downregulation of insulin-like signaling (ILS) is seen in Nucleotide Excision Repair (NER) deficient segmental progeroid mice. Evidence suggests that this is a survival response to persistent transcription-blocking DNA damage, although the relevant lesions have not been identified. Here we show that loss of NTH-1, the only Base Excision Repair (BER) ...

Exploiting DNA Repair and ER Stress Response Pathways to Induce Apoptosis in Glioblastoma Multiforme: A Dissertation

Glioblastoma multiforme (GBM) is a deadly grade IV brain tumor characterized by a heterogeneous population of cells that are drug resistant, aggressive, and infiltrative. The current standard of care, which has not changed in over a decade, only provides GBM patients with 12-14 months survival post diagnosis. We asked if the addition of a novel endoplasmic reticulum (ER) stress inducing agent, ...

Acetylation of hMOF Modulates H4K16ac to Regulate DNA Repair Genes in Response to Oxidative Stress

Oxidative stress is considered to be a key risk state for a variety of human diseases. In response to oxidative stress, the regulation of transcriptional expression of DNA repair genes would be important to DNA repair and genomic stability. However, the overall pattern of transcriptional expression of DNA repair genes and the underlying molecular response mechanism to oxidative stress remain un...

Response of Two Indica Rice Varieties to Salt Stress

  Salinity is one of the most challenging problems that adversely affects growth and development of plants. Therefore, understanding of the mechanisms that enable plants to adapt to salinity stress will ultimately help in the selection of stress tolerant cultivars for exploiting saline soils. The main objective of this study was to examine the effects of NaCl on some physiological and biochemic...

Response of two soybean cultivars to moisture stress